ANTI-MIGRATORY EFFECT OF VINFLUNINE IN ENDOTHELIAL AND GLIOBLASTOMA CELLS IS ASSOCIATED WITH CHANGES IN EB1 C-TERMINAL DETYROSINATED/TYROSINATED STATUS.

We previously showed that vinflunine, a microtubule-targeting drug of the Vinca-alkaloid family exerted its anti-angiogenic/anti-migratory activities through an increase in microtubule dynamics and an inhibition of microtubule targeting to adhesion sites.Such effect was associated with a reduction of EB1 comet length at microtubule (+) ends.In this

The essence and peculiarities of the fiscal regulation mechanism are studied.The scientific and theoretical bases of its influence on ensuring a balanced development of forestry in the system of fiscal policy of nature resource management are justified.The state of fiscal regulation in the sphere under investigation has been analyzed.It is found th

Shifting cultivation has been shown to be the primary cause of land use change in the Democratic Republic of Congo (DRC).Traditionally, forested and fallow land are rotated in a slash and burn cycle that has created an agricultural mosaic, including secondary forest, known deva curl arc angel as the rural complex.This study investigates the land us